Meta-analysis: Assocation between promoter hypermethylation of DAPK (Death-Associated Protein Kinase) and cervical cancer
نویسندگان
چکیده
منابع مشابه
Death-associated protein kinase promoter hypermethylation in normal human lymphocytes.
A high frequency of death-associated protein kinase (DAPK) promoter hypermethylation has been noted in B-cell malignancies, head and neck cancers, and other solid tumors, and it has been used as a tumor marker in molecular detection strategies. Low levels of DAPK promoter hypermethylation, ranging from 0.003 to 1.181%, were detected in peripheral blood cells from 75 of 143 (52%) normal subjects...
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Death-associated protein kinase 1 (DAPK) is an important serine/threonine kinase involved in various cellular processes, including apoptosis, autophagy, and inflammation. DAPK expression and activity are deregulated in a variety of diseases including cancer. Methylation of the DAPK gene is common in many types of cancer and can lead to loss of DAPK expression. However, the association between D...
متن کاملDifferential Hypermethylation of Death-Associated Protein Kinase Promoter in Central Neurocytoma and Oligodendroglioma
BACKGROUND Central neurocytoma and oligodendroglioma are rare tumors of the central nervous system. However, diagnosis between these two types of tumors is challenging due to their many cytological and histological similarities. Death-associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine protein kinase involved in many apoptosis pathways, and repressed expression o...
متن کاملPromoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype.
Expression of death-associated protein (DAP) kinase, a proapoptotic serine/threonine protein kinase, is frequently lost in human tumors. In a study of 134 primary breast cancer specimens hypermethylation of the DAP kinase gene was found in 13% of cases. A highly significant difference (P < 0.001) of DAP kinase inactivation was observed between invasive lobular cancer (n = 19) and invasive ducta...
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Cervical cancers remain the third leading cause of genital system cancer-related mortality in women, despite the widespread application of screening methods for the prevention and early detection of cervical cancer. Numerous epidemiological studies have proved that genital HPV infections, as the central etiological factor, were highly correlated with cervical cancer and were present in almost 9...
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ژورنال
عنوان ژورنال: ENGINEERING AND TECHNOLOGY
سال: 2020
ISSN: 2734-9608,2734-9330
DOI: 10.46223/hcmcoujs.tech.en.9.1.350.2019